Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q15063
UPID:
POSTN_HUMAN
Alternative names:
Osteoblast-specific factor 2
Alternative UPACC:
Q15063; B1ALD8; C0IMJ1; C0IMJ2; C0IMJ4; D2KRH7; F5H628; Q15064; Q29XZ0; Q3KPJ5; Q5VSY5; Q8IZF9
Background:
Periostin, also known as Osteoblast-specific factor 2, is a protein that plays a crucial role in cell adhesion, enhancing the incorporation of BMP1 in the fibronectin matrix of connective tissues. This process is vital for the proteolytic activation of lysyl oxidase LOX, which is essential for the structural integrity of connective tissues.
Therapeutic significance:
Understanding the role of Periostin could open doors to potential therapeutic strategies. Its involvement in cell adhesion and tissue integrity suggests its potential as a target in diseases related to connective tissue disorders.