Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q15286
UPID:
RAB35_HUMAN
Alternative names:
GTP-binding protein RAY; Ras-related protein Rab-1C
Alternative UPACC:
Q15286; B2R6E0; B4E390
Background:
Ras-related protein Rab-35, also known as GTP-binding protein RAY and Ras-related protein Rab-1C, plays a pivotal role in intracellular membrane trafficking. It regulates the transition between the inactive GDP-bound form and the active GTP-bound form, facilitating vesicle formation, movement, tethering, and fusion. Rab-35 is crucial for endocytosis, cytokinesis, and the fast recycling pathway, impacting cellular processes such as intercellular bridge stability and insulin-induced glucose transporter translocation in adipocytes.
Therapeutic significance:
Understanding the role of Ras-related protein Rab-35 could open doors to potential therapeutic strategies.