Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q15382
UPID:
RHEB_HUMAN
Alternative names:
Ras homolog enriched in brain
Alternative UPACC:
Q15382; B3KWN6; D3DX13; Q53Y56; Q99444
Background:
The GTP-binding protein Rheb, also known as Ras homolog enriched in brain, is a pivotal regulator of mTORC1 signaling pathway. It activates protein kinase activity of mTORC1, influencing apoptosis regulation. Rheb stimulates phosphorylation of S6K1 and EIF4EBP1, showcasing its role in cellular growth and metabolism with low intrinsic GTPase activity.
Therapeutic significance:
Understanding the role of GTP-binding protein Rheb could open doors to potential therapeutic strategies.