Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q15438
UPID:
CYH1_HUMAN
Alternative names:
PH, SEC7 and coiled-coil domain-containing protein 1; SEC7 homolog B2-1
Alternative UPACC:
Q15438; A6NFW7; B7Z1T4; Q9P123; Q9P124
Background:
Cytohesin-1, also known as PH, SEC7 and coiled-coil domain-containing protein 1 or SEC7 homolog B2-1, plays a pivotal role in cellular processes by promoting guanine-nucleotide exchange on ARF1, ARF5, and ARF6. This action facilitates the activation of ARF factors, crucial for membrane trafficking, junctional remodeling, and epithelial polarization through the regulation of ARF6 activity.
Therapeutic significance:
Understanding the role of Cytohesin-1 could open doors to potential therapeutic strategies.