Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q15545
UPID:
TAF7_HUMAN
Alternative names:
RNA polymerase II TBP-associated factor subunit F; Transcription initiation factor TFIID 55 kDa subunit
Alternative UPACC:
Q15545; B2RBV9; Q13036
Background:
Transcription initiation factor TFIID subunit 7, also known as RNA polymerase II TBP-associated factor subunit F, plays a pivotal role in the initiation of RNA polymerase II-dependent transcription. It is a part of the TFIID basal transcription factor complex, which is essential for recognizing and binding promoters, facilitating the assembly of the pre-initiation complex. This complex includes TBP, a TATA-box-binding protein, and various TBP-associated factors (TAFs), highlighting the intricate coordination required for gene expression initiation.
Therapeutic significance:
Understanding the role of Transcription initiation factor TFIID subunit 7 could open doors to potential therapeutic strategies.