Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q15561
UPID:
TEAD4_HUMAN
Alternative names:
TEA domain family member 4; Transcription factor 13-like 1; Transcription factor RTEF-1
Alternative UPACC:
Q15561; H0Y308; Q6MZR9; Q8NEV5; Q92883; Q96BK2
Background:
Transcriptional enhancer factor TEF-3, also known as TEA domain family member 4, plays a pivotal role in the Hippo signaling pathway. This pathway is crucial for organ size control and tumor suppression, functioning through a kinase cascade that ultimately inhibits YAP1 oncoprotein and WWTR1/TAZ. TEF-3 is essential for mediating the gene expression of these proteins, influencing cell proliferation, migration, and the induction of epithelial mesenchymal transition (EMT).
Therapeutic significance:
Understanding the role of Transcriptional enhancer factor TEF-3 could open doors to potential therapeutic strategies.