Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q15691
UPID:
MARE1_HUMAN
Alternative names:
APC-binding protein EB1; End-binding protein 1
Alternative UPACC:
Q15691; B2R6I7; E1P5M8; Q3KQS8
Background:
Microtubule-associated protein RP/EB family member 1, also known as APC-binding protein EB1 and End-binding protein 1, plays a pivotal role in microtubule dynamics. It binds to microtubule plus-ends, regulating their growth and shrinkage, essential for cell division and intracellular transport. This protein is crucial for mitotic spindle positioning, microtubule nucleation, and elongation, and it interacts with various proteins to organize the microtubule network, facilitating polarized cell movement and autophagosome transport.
Therapeutic significance:
Understanding the role of Microtubule-associated protein RP/EB family member 1 could open doors to potential therapeutic strategies.