Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q16514
UPID:
TAF12_HUMAN
Alternative names:
Transcription initiation factor TFIID 20/15 kDa subunits
Alternative UPACC:
Q16514; D3DPM5; Q15775; Q5T077
Background:
Transcription initiation factor TFIID subunit 12 is a pivotal component of the TFIID basal transcription factor complex, essential for the initiation of RNA polymerase II-dependent transcription. It binds promoters with or without a TATA box via TBP, facilitating the assembly of the pre-initiation complex. The complex includes TBP and various TAFs, playing roles in different transcription coactivator complexes.
Therapeutic significance:
Understanding the role of Transcription initiation factor TFIID subunit 12 could open doors to potential therapeutic strategies.