Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q16610
UPID:
ECM1_HUMAN
Alternative names:
Secretory component p85
Alternative UPACC:
Q16610; A8K8S0; B4DW49; B4DY60; O43266; Q5T5G4; Q5T5G5; Q5T5G6; Q8IZ60
Background:
Extracellular matrix protein 1, also known as Secretory component p85, plays a pivotal role in endochondral bone formation, acting as a negative regulator of bone mineralization. It also stimulates endothelial cell proliferation and promotes angiogenesis, while inhibiting MMP9 proteolytic activity.
Therapeutic significance:
Linked to Lipoid proteinosis, a rare autosomal recessive disorder, Extracellular matrix protein 1's dysfunction showcases its critical role in skin, mucosae, and visceral health. Understanding the role of Extracellular matrix protein 1 could open doors to potential therapeutic strategies for this and related conditions.