Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
Q16719
UPID:
KYNU_HUMAN
Alternative names:
L-kynurenine hydrolase
Alternative UPACC:
Q16719; B2RCZ5; D3DP79; Q6I9T2; Q9BVW3
Background:
Kynureninase, also known as L-kynurenine hydrolase, plays a pivotal role in the metabolism of amino acids, specifically catalyzing the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic acid and 3-hydroxyanthranilic acid. This enzyme's preference for the L-3-hydroxy form and its cysteine-conjugate-beta-lyase activity underscore its critical function in biological systems.
Therapeutic significance:
Kynureninase's involvement in Hydroxykynureninuria and Vertebral, cardiac, renal, and limb defects syndrome 2 highlights its potential as a therapeutic target. Understanding the role of Kynureninase could open doors to potential therapeutic strategies for these conditions.