Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q2M1K9
UPID:
ZN423_HUMAN
Alternative names:
Olf1/EBF-associated zinc finger protein; Smad- and Olf-interacting zinc finger protein
Alternative UPACC:
Q2M1K9; O94860; Q76N04; Q9NZ13
Background:
Zinc finger protein 423, also known as Olf1/EBF-associated zinc finger protein or Smad- and Olf-interacting zinc finger protein, plays a pivotal role in BMP signaling and olfactory neurogenesis. It functions as a transcription factor that can act as an activator or repressor. It is crucial in the transition from differentiation to maturation in olfactory receptor neurons and in the formation of the cerebellar vermis.
Therapeutic significance:
Zinc finger protein 423 is implicated in Nephronophthisis 14 and Joubert syndrome 19, diseases characterized by kidney disorders and cerebellar vermis hypoplasia. Understanding the role of Zinc finger protein 423 could open doors to potential therapeutic strategies for these conditions.