Focused On-demand Library for WASH complex subunit 4

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.

From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.

The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.

Our top-notch dedicated system is used to design specialised libraries.

Fig. 1. The sreening workflow of Receptor.AI

Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.

Key features that set our library apart include:

The Receptor.AI platform integrates extensive information about the target protein, such as historical experiments, academic research, known ligands, and structural insights, thereby increasing the likelihood of identifying highly relevant compounds.
The platform’s sophisticated molecular simulations are designed to discover potential binding sites, ensuring that our focused library is optimal for the discovery of allosteric inhibitors and binders for cryptic pockets.
With over 50 customisable AI models, verified through extensive testing in commercial drug discovery and research, Receptor.AI is efficient, reliable, and precise. These models are essential in the production of our focused libraries.
Receptor.AI not only produces focused libraries but also provides full services and solutions at every stage of preclinical drug discovery, with a success-based pricing structure that aligns our interests with the success of your project.

partner

Reaxense

upacc

Q2M389

UPID:

WASC4_HUMAN

Alternative names:

Strumpellin and WASH-interacting protein; WASH complex subunit SWIP

Alternative UPACC:

Q2M389; Q2NL83; Q8IW61; Q8N5W7; Q9NVD6; Q9UPW7

Background:

The WASH complex subunit 4, also known as Strumpellin and WASH-interacting protein, plays a pivotal role in cellular processes. It is a crucial component of the WASH core complex, acting as a nucleation-promoting factor (NPF) at endosome surfaces. Here, it recruits and activates the Arp2/3 complex to induce actin polymerization, essential for the fission of tubules that facilitate endosome sorting.

Therapeutic significance:

Linked to Intellectual developmental disorder, autosomal recessive 43, WASH complex subunit 4's genetic variants underscore its clinical relevance. Understanding its role could unveil novel therapeutic strategies.