Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q2MV58
UPID:
TECT1_HUMAN
Alternative names:
-
Alternative UPACC:
Q2MV58; A8MX11; Q49A60; Q6P5X1; Q6UXW2; Q8NAE9; Q96N72; Q9H798
Background:
Tectonic-1, a pivotal component of the tectonic-like complex, plays a crucial role at the primary cilia's transition zone, acting as a barrier to protein diffusion between cilia and plasma membranes. It is instrumental in the Hedgehog (Hh) pathway, essential for neural tube patterning, by modulating Hh signal transduction for activation or repression based on Hh levels.
Therapeutic significance:
Tectonic-1's malfunction is linked to Joubert syndrome 13, characterized by cerebellar ataxia, oculomotor apraxia, and other neurological symptoms. Understanding Tectonic-1's role could unveil new therapeutic strategies for this and potentially other ciliopathies.