Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q2TBA0
UPID:
KLH40_HUMAN
Alternative names:
Kelch repeat and BTB domain-containing protein 5; Sarcosynapsin
Alternative UPACC:
Q2TBA0; Q86SI1; Q96MR2
Background:
Kelch-like protein 40, also known as Kelch repeat and BTB domain-containing protein 5 or Sarcosynapsin, plays a pivotal role in skeletal muscle development. It functions as a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex, crucial for mediating ubiquitination and degradation of TFDP1. This action regulates the E2F:DP transcription factor complex activity. Additionally, it promotes the stabilization of LMOD3 by acting as a negative regulator of its ubiquitination.
Therapeutic significance:
Kelch-like protein 40's involvement in Nemaline myopathy 8, a severe muscular disorder, underscores its therapeutic significance. Understanding the protein's role could lead to groundbreaking therapeutic strategies for treating muscle weakness and developmental complications associated with this condition.