Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q2VPK5
UPID:
CTU2_HUMAN
Alternative names:
Cytosolic thiouridylase subunit 2
Alternative UPACC:
Q2VPK5; B2RXK0; Q0P511; Q66K78; Q6P4C8; Q86SV4
Background:
Cytoplasmic tRNA 2-thiolation protein 2, also known as Cytosolic thiouridylase subunit 2, plays a pivotal role in the 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu), and tRNA(Gln). This process is crucial for the accurate translation of the genetic code into proteins, ensuring cellular function and viability.
Therapeutic significance:
The protein's involvement in Microcephaly, facial dysmorphism, renal agenesis, and ambiguous genitalia syndrome highlights its critical role in human development and disease. Understanding the role of Cytoplasmic tRNA 2-thiolation protein 2 could open doors to potential therapeutic strategies for this and related disorders.