Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q2YD98
UPID:
UVSSA_HUMAN
Alternative names:
-
Alternative UPACC:
Q2YD98; A8K9E6; B2RU11; Q8WTX4; Q9P1Z8
Background:
UV-stimulated scaffold protein A plays a pivotal role in transcription-coupled nucleotide excision repair (TC-NER), crucial for removing lesions from the transcribed strand of active genes. It aids in the ubiquitination of RNA polymerase II at DNA damage sites, facilitating lesion repair by promoting RNA pol IIo backtracking. This protein also enhances ERCC6 stability by recruiting USP7, preventing UV-induced degradation.
Therapeutic significance:
Given its involvement in UV-sensitive syndrome 3, a disorder marked by cutaneous photosensitivity, understanding the role of UV-stimulated scaffold protein A could open doors to potential therapeutic strategies.