Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q49AH0
UPID:
CDNF_HUMAN
Alternative names:
ARMET-like protein 1; Conserved dopamine neurotrophic factor
Alternative UPACC:
Q49AH0; A2RUU0; B4DVW3
Background:
Cerebral dopamine neurotrophic factor, also known as ARMET-like protein 1 and Conserved dopamine neurotrophic factor, plays a crucial role in the survival and function of dopamine neurons. It acts as a trophic factor, preventing the degeneration of dopaminergic neurons induced by 6-hydroxydopamine (6-OHDA), a toxin that specifically targets these cells.
Therapeutic significance:
Understanding the role of Cerebral dopamine neurotrophic factor could open doors to potential therapeutic strategies. Its ability to restore dopaminergic function and prevent neuron degeneration in the substantia nigra highlights its potential in treating neurodegenerative disorders.