Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q56UN5
UPID:
M3K19_HUMAN
Alternative names:
Regulated in COPD, protein kinase; SPS1/STE20-related protein kinase YSK4
Alternative UPACC:
Q56UN5; B2RP57; B7ZMH9; E2QRE3; Q56UN1; Q56UN2; Q56UN3; Q56UN4; Q8N4E9; Q9H5T2
Background:
Mitogen-activated protein kinase kinase kinase 19, also known by its alternative names Regulated in COPD, protein kinase and SPS1/STE20-related protein kinase YSK4, plays a crucial role in cellular signaling pathways. This kinase is part of a larger family of MAP kinases, which are involved in various cellular processes such as proliferation, differentiation, and stress responses.
Therapeutic significance:
Understanding the role of Mitogen-activated protein kinase kinase kinase 19 could open doors to potential therapeutic strategies. Its involvement in key signaling pathways suggests its potential as a target in treating diseases where these pathways are dysregulated.