Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q58FF6
UPID:
H90B4_HUMAN
Alternative names:
-
Alternative UPACC:
Q58FF6
Background:
The Putative heat shock protein HSP 90-beta 4 serves as a molecular chaperone, playing a crucial role in the maturation, structural maintenance, and regulation of specific target proteins. Its involvement in these fundamental cellular processes highlights its importance in maintaining cellular integrity and function.
Therapeutic significance:
Understanding the role of Putative heat shock protein HSP 90-beta 4 could open doors to potential therapeutic strategies. Its function as a molecular chaperone suggests its potential in correcting protein misfolding, a common feature in many diseases.