Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q5T4W7
UPID:
ARTN_HUMAN
Alternative names:
Enovin; Neublastin
Alternative UPACC:
Q5T4W7; D3DPY1; D3DPY3; O95441; O96030; Q6P6A3
Background:
Artemin, known alternatively as Enovin or Neublastin, plays a crucial role in the nervous system. It acts as a ligand for the GFR-alpha-3-RET and GFR-alpha-1-RET receptor complexes, promoting the survival of sensory, sympathetic peripheral, and dopaminergic neurons. Additionally, Artemin is a strong attractant of gut hematopoietic cells, aiding in the formation of Peyer's patch-like structures, essential for gut-associated lymphoid tissue.
Therapeutic significance:
Understanding the role of Artemin could open doors to potential therapeutic strategies.