Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
Q5T848
UPID:
MGLYR_HUMAN
Alternative names:
G-protein coupled receptor 158
Alternative UPACC:
Q5T848; Q6QR81; Q9ULT3
Background:
The Metabotropic glycine receptor, also known as G-protein coupled receptor 158, is a key player in brain function, particularly in synapse formation and regulation. It operates uniquely by recruiting the RGS7-GNB5 complex, diverging from typical G-protein activation. This receptor's interaction with glycine or taurine shifts its intracellular conformation, influencing cAMP levels and thus, neuronal excitability and synaptic transmission. Its role extends to mood and cognition regulation, spatial learning, and synaptic organization in the hippocampus.
Therapeutic significance:
Understanding the role of Metabotropic glycine receptor could open doors to potential therapeutic strategies.