Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q5T8I9
UPID:
HENMT_HUMAN
Alternative names:
HEN1 methyltransferase homolog 1
Alternative UPACC:
Q5T8I9; A8MRR6; B1AM16; B1AM17; Q96EJ7; Q96NN0
Background:
Small RNA 2'-O-methyltransferase, also known as HEN1 methyltransferase homolog 1, plays a pivotal role in the biogenesis of piRNAs. These piRNAs, ranging from 24 to 30 nucleotides, originate from transposons and repeated sequence elements through a Dicer-independent mechanism. The enzyme's methyltransferase activity adds a 2'-O-methyl group at the 3'-end of piRNAs, crucial for their stability by protecting them from uridylation and degradation. This stabilization is vital for gametogenesis, highlighting the enzyme's significance in reproductive biology.
Therapeutic significance:
Understanding the role of Small RNA 2'-O-methyltransferase could open doors to potential therapeutic strategies.