Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q5TBC7
UPID:
B2L15_HUMAN
Alternative names:
Bcl-2 family kin
Alternative UPACC:
Q5TBC7; A0PJY6; A8K074; I6LA82
Background:
Bcl-2-like protein 15, also known as Bcl-2 family kin, plays a crucial role in the regulation of apoptosis. This protein is part of the Bcl-2 family, a group known for their involvement in the cell death pathway, balancing between survival and apoptosis. The specific functions of Bcl-2-like protein 15 remain to be fully elucidated, making it a subject of intense research.
Therapeutic significance:
Understanding the role of Bcl-2-like protein 15 could open doors to potential therapeutic strategies. Its involvement in apoptosis regulation suggests that it could be a target for cancer therapy, where the control of cell death is a pivotal concern.