Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q5VWG9
UPID:
TAF3_HUMAN
Alternative names:
140 kDa TATA box-binding protein-associated factor; TBP-associated factor 3; Transcription initiation factor TFIID 140 kDa subunit
Alternative UPACC:
Q5VWG9; Q05DA0; Q6GMS5; Q6P6B5; Q86VY6; Q9BQS9; Q9UFI8
Background:
Transcription initiation factor TFIID subunit 3, also known as TAF3, is a pivotal component of the TFIID basal transcription factor complex. This complex is essential for the initiation of RNA polymerase II-dependent transcription, recognizing and binding promoters with or without a TATA box. TFIID is composed of TBP and multiple TAFs, forming three distinct modules. TAF3, in conjunction with TAF5 and TBP, constitutes the TFIID-A module, playing a crucial role in the differentiation of myoblasts into myocytes.
Therapeutic significance:
Understanding the role of Transcription initiation factor TFIID subunit 3 could open doors to potential therapeutic strategies.