Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q5VXI9
UPID:
LIPN_HUMAN
Alternative names:
Lipase-like abhydrolase domain-containing protein 4
Alternative UPACC:
Q5VXI9; A7KIH9
Background:
Lipase member N, also known as Lipase-like abhydrolase domain-containing protein 4, plays a pivotal role in the final step of keratinocyte differentiation. Its unique function in lipid metabolism of the epidermis's most differentiated layers underscores its importance in skin health.
Therapeutic significance:
Linked to Ichthyosis, congenital, autosomal recessive 8, a disorder marked by abnormal skin scaling, Lipase member N's role in skin differentiation and lipid metabolism makes it a target for therapeutic intervention. Understanding the role of Lipase member N could open doors to potential therapeutic strategies.