Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q5XKP0
UPID:
MIC13_HUMAN
Alternative names:
Protein P117
Alternative UPACC:
Q5XKP0; A0A0B4J2A5; K7EKR0; Q86YE5
Background:
MICOS complex subunit MIC13, also known as Protein P117, is integral to the mitochondrial inner membrane. It plays a pivotal role in maintaining crista junctions and the inner membrane's architecture, crucial for cellular energy production. MIC13 is essential for incorporating MICOS10/MIC10 into the MICOS complex, thereby ensuring the proper formation and maintenance of cristae morphology.
Therapeutic significance:
The dysfunction of MIC13 is linked to Combined oxidative phosphorylation deficiency 37, a severe mitochondrial disorder characterized by neurodegeneration, liver dysfunction, and often early mortality. Understanding MIC13's role could pave the way for novel therapeutic strategies targeting mitochondrial diseases.