Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q6GQQ9
UPID:
OTU7B_HUMAN
Alternative names:
Cellular zinc finger anti-NF-kappa-B protein; Zinc finger A20 domain-containing protein 1; Zinc finger protein Cezanne
Alternative UPACC:
Q6GQQ9; B7Z643; D3DUZ8; Q5SZ60; Q8WWA7; Q9NQ53; Q9UFF4
Background:
OTU domain-containing protein 7B, also known as Cellular zinc finger anti-NF-kappa-B protein, plays a crucial role in regulating the non-canonical NF-kappa-B pathway. It mediates deubiquitination of TRAF3, maintaining the balance of B-cell responses and mucosal immunity. Additionally, it influences T cell receptor signaling through deubiquitination of ZAP70, impacting T cell homeostasis and cytokine production.
Therapeutic significance:
Understanding the role of OTU domain-containing protein 7B could open doors to potential therapeutic strategies. Its involvement in key immune pathways suggests its potential as a target in modulating immune responses.