Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q6IA86
UPID:
ELP2_HUMAN
Alternative names:
SHINC-2; STAT3-interacting protein 1
Alternative UPACC:
Q6IA86; A8KAI6; B4DTG0; B4DXP0; E7EP23; E9PCX0; Q53GZ0; Q687Y8; Q8N5C2; Q96GV4; Q96PI7; Q9H9N0; Q9NV81
Background:
Elongator complex protein 2 (ECP2), also known as SHINC-2 and STAT3-interacting protein 1, plays a crucial role in the modification of transfer RNAs (tRNAs). It is a key component of the elongator complex, essential for the formation of carboxymethyluridine in tRNA's wobble base, influencing protein synthesis and cellular function.
Therapeutic significance:
ECP2's involvement in Intellectual developmental disorder, autosomal recessive 58, underscores its potential as a target for therapeutic intervention. Understanding the role of Elongator complex protein 2 could open doors to potential therapeutic strategies.