Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q6P1K2
UPID:
PMF1_HUMAN
Alternative names:
-
Alternative UPACC:
Q6P1K2; A8K0C5; Q5TCJ8; Q5TCJ9; Q5TCK0; Q5TCK1; Q5TCK3; Q69YZ9; Q6PHR4; Q6ZVE6; Q86VJ6; Q8N4T6; Q9UBQ3
Background:
Polyamine-modulated factor 1 plays a crucial role in mitosis, ensuring proper chromosome alignment, segregation, and kinetochore formation. It functions within the MIS12 complex and may partner with NFE2L2 to regulate polyamine-induced transcription of SSAT, highlighting its importance in cellular division and gene expression.
Therapeutic significance:
Understanding the role of Polyamine-modulated factor 1 could open doors to potential therapeutic strategies. Its involvement in critical cellular processes underscores its potential as a target for interventions in diseases where these processes are dysregulated.