Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q6P1M3
UPID:
L2GL2_HUMAN
Alternative names:
HGL; Lethal(2) giant larvae protein homolog 2
Alternative UPACC:
Q6P1M3; Q14521; Q9BR62
Background:
LLGL scribble cell polarity complex component 2 (LLGL2), also known as HGL or Lethal(2) giant larvae protein homolog 2, plays a pivotal role in cell division and epithelial cell polarity. It is part of a complex including GPSM2/LGN, PRKCI/aPKC, and PARD6B/Par-6, crucial for the organization and orientation of bipolar spindles.
Therapeutic significance:
Understanding the role of LLGL2 could open doors to potential therapeutic strategies.