Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q6PCT2
UPID:
FXL19_HUMAN
Alternative names:
F-box and leucine-rich repeat protein 19
Alternative UPACC:
Q6PCT2; A8MT10; Q8N789; Q9NT14
Background:
F-box/LRR-repeat protein 19, also known as F-box and leucine-rich repeat protein 19, is a crucial component of the SCF E3 ubiquitin ligase complex, influencing cell migration, proliferation, and cytoskeletal reorganization. It targets RHOA, RAC1, and RAC3 for degradation, regulating cell migration and TGFB1-induced E-cadherin down-regulation. Additionally, it plays a role in DNA binding, gene induction during cell differentiation, and histone modification.
Therapeutic significance:
Understanding the role of F-box/LRR-repeat protein 19 could open doors to potential therapeutic strategies.