Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q6PGP7
UPID:
SKI3_HUMAN
Alternative names:
Tetratricopeptide repeat protein 37; Tricho-hepatic-enteric syndrome protein
Alternative UPACC:
Q6PGP7; O15077; Q6PJI3
Background:
Superkiller complex protein 3, also known as Tetratricopeptide repeat protein 37 and Tricho-hepatic-enteric syndrome protein, plays a crucial role in mRNA decay and quality control. It is a component of the SKI complex, aiding in mRNA extraction from ribosomes and facilitating its degradation. This protein is also involved in ribosome recycling and associates with transcriptionally active genes.
Therapeutic significance:
Linked to Trichohepatoenteric syndrome 1, characterized by growth retardation, severe diarrhea, and immunodeficiency, Superkiller complex protein 3's understanding could pave the way for innovative treatments targeting its genetic variants.