Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q6PH85
UPID:
DCNL2_HUMAN
Alternative names:
DCUN1 domain-containing protein 2; Defective in cullin neddylation protein 1-like protein 2
Alternative UPACC:
Q6PH85; Q5JSA5; Q5JSA6; Q5JSA7; Q9NVJ1; Q9NXR6
Background:
DCN1-like protein 2, also known as DCUN1 domain-containing protein 2 or Defective in cullin neddylation protein 1-like protein 2, plays a pivotal role in protein neddylation. It facilitates the transfer of NEDD8, a ubiquitin-like protein, to cullin proteins within the SCF (SKP1-CUL1-F-box protein) complexes, crucial for cell cycle regulation and signal transduction.
Therapeutic significance:
Understanding the role of DCN1-like protein 2 could open doors to potential therapeutic strategies.