Focused On-demand Library for Synaptonemal complex central element protein 2

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.

We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.

The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.

We utilise our cutting-edge, exclusive workflow to develop focused libraries.

Fig. 1. The sreening workflow of Receptor.AI

Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.

Key features that set our library apart include:

The Receptor.AI platform integrates extensive information about the target protein, such as historical experiments, academic research, known ligands, and structural insights, thereby increasing the likelihood of identifying highly relevant compounds.
The platform’s sophisticated molecular simulations are designed to discover potential binding sites, ensuring that our focused library is optimal for the discovery of allosteric inhibitors and binders for cryptic pockets.
With over 50 customisable AI models, verified through extensive testing in commercial drug discovery and research, Receptor.AI is efficient, reliable, and precise. These models are essential in the production of our focused libraries.
Receptor.AI not only produces focused libraries but also provides full services and solutions at every stage of preclinical drug discovery, with a success-based pricing structure that aligns our interests with the success of your project.

partner

Reaxense

upacc

Q6PIF2

UPID:

SYCE2_HUMAN

Alternative names:

Central element synaptonemal complex protein 1

Alternative UPACC:

Q6PIF2; B4DYD3

Background:

Synaptonemal complex central element protein 2, also known as Central element synaptonemal complex protein 1, plays a pivotal role in meiosis. It is a major component of the transverse central element of synaptonemal complexes (SCS), essential for the pairing of homologous chromosomes during meiotic prophase. This protein's incorporation into the central element is contingent upon SYCP1, highlighting its significance in synaptonemal complex assembly, stabilization, and recombination.

Therapeutic significance:

Understanding the role of Synaptonemal complex central element protein 2 could open doors to potential therapeutic strategies. Its critical function in genetic recombination and chromosome pairing during meiosis presents a unique opportunity for interventions in genetic disorders.