Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
Q6PIW4
UPID:
FIGL1_HUMAN
Alternative names:
-
Alternative UPACC:
Q6PIW4; D3DVM6; Q86V18; Q8ND59; Q9H8P1; Q9H917
Background:
Fidgetin-like protein 1 plays a crucial role in DNA repair mechanisms, specifically in DNA double-strand break repair via homologous recombination. It is uniquely recruited at sites of DNA damage independently of other key proteins in this pathway, such as BRCA2 and RAD51, in a process that requires H2AX. Beyond its involvement in DNA repair, this protein is implicated in regulating osteoblast proliferation and differentiation, as well as playing a role in male meiosis dynamics.
Therapeutic significance:
Understanding the role of Fidgetin-like protein 1 could open doors to potential therapeutic strategies, particularly in enhancing DNA repair mechanisms for conditions characterized by genomic instability. Its involvement in osteoblast proliferation and differentiation suggests potential applications in bone health and repair.