Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q6PJ69
UPID:
TRI65_HUMAN
Alternative names:
Tripartite motif-containing protein 65
Alternative UPACC:
Q6PJ69; Q4G0F0; Q6DKJ6; Q9BRP6
Background:
E3 ubiquitin-protein ligase TRIM65, also known as Tripartite motif-containing protein 65, plays a pivotal role in innate immunity, autophagy, and inflammation. It regulates miRNAs by affecting the ubiquitination and stability of TNRC6A, crucial for RNA-mediated gene silencing. TRIM65's ubiquitination activity suppresses miR-138-5p expression, enhancing autophagy. It also activates IFIH1/MDA5 through 'Lys-63'-mediated ubiquitination upon enteroviral infection, and limits inflammation by promoting the degradation of VCAM1 and inhibiting NLRP3 inflammasome activation.
Therapeutic significance:
Understanding the role of E3 ubiquitin-protein ligase TRIM65 could open doors to potential therapeutic strategies.