Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q6QNY0
UPID:
BL1S3_HUMAN
Alternative names:
-
Alternative UPACC:
Q6QNY0; B2RXB8
Background:
Biogenesis of lysosome-related organelles complex 1 subunit 3 plays a crucial role in the formation and function of lysosome-related organelles, such as melanosomes and platelet dense granules. It is part of the BLOC-1 complex, essential for directing membrane protein cargos into vesicles for delivery into neurites and nerve terminals, and is involved in neurite extension.
Therapeutic significance:
The protein is implicated in Hermansky-Pudlak syndrome 8, characterized by oculocutaneous albinism, bleeding disorders, and lysosomal storage defects. Understanding its role could lead to novel therapeutic strategies for this syndrome.