Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
Q6SA08
UPID:
TSSK4_HUMAN
Alternative names:
Serine/threonine-protein kinase 22E
Alternative UPACC:
Q6SA08; Q2TA60; Q6ZNM2
Background:
Testis-specific serine/threonine-protein kinase 4, alternatively known as Serine/threonine-protein kinase 22E, plays a crucial role in male germ cell development and mature sperm function. This kinase is implicated in the Cre/Creb signaling pathway, phosphorylating CREB1 on 'Ser-133' and CREM on 'Ser-116', thereby potentially enhancing the Cre/Creb pathway's activity in cells. Its involvement extends to phosphorylating ODF2 on 'Ser-95', highlighting its significance in cellular signaling processes.
Therapeutic significance:
Understanding the role of Testis-specific serine/threonine-protein kinase 4 could open doors to potential therapeutic strategies, particularly in the realm of reproductive health and male fertility. Its pivotal role in sperm function and development positions it as a key target for addressing male infertility issues.