Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q6UXT9
UPID:
ABH15_HUMAN
Alternative names:
Alpha/beta hydrolase domain-containing protein 15
Alternative UPACC:
Q6UXT9; Q96EC5
Background:
Protein ABHD15, also known as Alpha/beta hydrolase domain-containing protein 15, plays a crucial role in metabolic processes. It is implicated in the regulation of adipocyte lipolysis and liver lipid accumulation, highlighting its importance in lipid metabolism.
Therapeutic significance:
Understanding the role of Protein ABHD15 could open doors to potential therapeutic strategies. Its involvement in lipid metabolism suggests it could be a target for treating metabolic disorders.