Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q6UXV0
UPID:
GFRAL_HUMAN
Alternative names:
-
Alternative UPACC:
Q6UXV0; Q5VTF6
Background:
The GDNF family receptor alpha-like plays a pivotal role in the regulation of food intake, energy expenditure, and body weight. It acts as a brainstem-restricted receptor for GDF15, responding to metabolic and toxin-induced stresses. This interaction with GDF15 leads to the activation of cellular signaling pathways, including MAPK and AKT, crucial for maintaining metabolic balance.
Therapeutic significance:
Understanding the role of GDNF family receptor alpha-like could open doors to potential therapeutic strategies. Its involvement in critical metabolic pathways highlights its potential as a target for addressing disorders related to energy balance and weight management.