Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q6ZNE9
UPID:
RUFY4_HUMAN
Alternative names:
-
Alternative UPACC:
Q6ZNE9; Q6ZR96
Background:
The RUN and FYVE domain-containing protein 4 plays a pivotal role in cellular homeostasis by positively regulating macroautophagy in primary dendritic cells. It enhances autophagic flux, likely through promoting autophagosome formation and improving lysosomal fusion, facilitated by its binding to phosphatidylinositol 3-phosphate (PtdIns3P) via its FYVE-type zinc finger.
Therapeutic significance:
Understanding the role of RUN and FYVE domain-containing protein 4 could open doors to potential therapeutic strategies.