Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q6ZQW0
UPID:
I23O2_HUMAN
Alternative names:
Indoleamine 2,3-dioxygenase-like protein 1; Indoleamine-pyrrole 2,3-dioxygenase-like protein 1
Alternative UPACC:
Q6ZQW0; A4UD41; F5H5G0
Background:
Indoleamine 2,3-dioxygenase 2 (IDO2) plays a pivotal role in the catabolism of the essential amino acid tryptophan along the kynurenine pathway, as highlighted in recent studies (PubMed:17671174). Its involvement in immune regulation positions it as a critical mediator in biological systems. Despite its significant functions, IDO2's role in tryptophan-related tumoral resistance appears to be minimal (PubMed:25691885).
Therapeutic significance:
Understanding the role of Indoleamine 2,3-dioxygenase 2 could open doors to potential therapeutic strategies. Its central function in tryptophan catabolism and immune regulation underscores its potential as a target in disease-modifying treatments.