Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q6ZU64
UPID:
CFA65_HUMAN
Alternative names:
Coiled-coil domain-containing protein 108
Alternative UPACC:
Q6ZU64; A2BDD8; E9PCR1; E9PG25; E9PG72; Q6ZSR8; Q8N0T4; Q8NDJ3
Background:
Cilia- and flagella-associated protein 65, also known as Coiled-coil domain-containing protein 108, is pivotal in flagellar formation and sperm motility. This protein's involvement in the structural and functional integrity of flagella underscores its critical role in male fertility.
Therapeutic significance:
Linked to Spermatogenic failure 40, a disorder marked by reduced or absent sperm motility due to morphologic anomalies, understanding the role of Cilia- and flagella-associated protein 65 could open doors to potential therapeutic strategies.