Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q71UI9
UPID:
H2AV_HUMAN
Alternative names:
H2A.F/Z; H2A.Z variant histone 2
Alternative UPACC:
Q71UI9; A6NFA8; A6NKY0; A6NN01; A8MQC5; Q59GV8; Q6PK98
Background:
Histone H2A.V, also known as H2A.F/Z or H2A.Z variant histone 2, plays a pivotal role in chromatin structure and function. It replaces conventional H2A in a subset of nucleosomes, impacting DNA accessibility for transcription, repair, replication, and chromosomal stability. Its involvement in nucleosome remodeling and the histone code signifies its central role in regulating DNA accessibility.
Therapeutic significance:
Understanding the role of Histone H2A.V could open doors to potential therapeutic strategies.