Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q71UI9
UPID:
H2AV_HUMAN
Alternative names:
H2A.F/Z; H2A.Z variant histone 2
Alternative UPACC:
Q71UI9; A6NFA8; A6NKY0; A6NN01; A8MQC5; Q59GV8; Q6PK98
Background:
Histone H2A.V, also known as H2A.F/Z or H2A.Z variant histone 2, plays a pivotal role in chromatin structure and function. It replaces conventional H2A in a subset of nucleosomes, impacting DNA accessibility for transcription, repair, replication, and chromosomal stability. Its involvement in nucleosome remodeling and the histone code signifies its central role in regulating DNA accessibility.
Therapeutic significance:
Understanding the role of Histone H2A.V could open doors to potential therapeutic strategies.