Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q765P7
UPID:
MTSS2_HUMAN
Alternative names:
Actin-bundling with BAIAP2 homology protein 1; MTSS1-like protein
Alternative UPACC:
Q765P7; A6NJI7; Q9BUA8
Background:
Protein MTSS 2, also known as Actin-bundling with BAIAP2 homology protein 1 or MTSS1-like protein, plays a crucial role in plasma membrane dynamics. It enhances PDGF-mediated membrane ruffle and lamellipodia formation in fibroblasts through RAC1 activation, and may also be involved in actin bundling. This protein's activities are pivotal for cellular morphology and motility.
Therapeutic significance:
Protein MTSS 2 is linked to Intellectual developmental disorder with ocular anomalies and distinctive facial features, a condition marked by developmental delays, intellectual disability, and various physical anomalies. Understanding the role of Protein MTSS 2 could open doors to potential therapeutic strategies for this disorder.