Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q76I76
UPID:
SSH2_HUMAN
Alternative names:
SSH-like protein 2
Alternative UPACC:
Q76I76; Q8TDB5; Q8WYL1; Q8WYL2; Q96F40; Q96H36; Q9C0D8
Background:
Protein phosphatase Slingshot homolog 2, also known as SSH-like protein 2, plays a pivotal role in actin filament dynamics. It dephosphorylates and activates cofilin, a crucial actin-binding and depolymerizing factor, facilitating actin filament disassembly. This process is essential for various cellular functions, including spermatogenesis and acrosome biogenesis, by regulating actin cytoskeleton remodeling.
Therapeutic significance:
Understanding the role of Protein phosphatase Slingshot homolog 2 could open doors to potential therapeutic strategies. Its involvement in critical cellular processes such as actin filament dynamics and spermatogenesis highlights its potential as a target for therapeutic intervention in related disorders.