Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q7L2J0
UPID:
MEPCE_HUMAN
Alternative names:
Bicoid-interacting protein 3 homolog
Alternative UPACC:
Q7L2J0; B3KP86; D6W5V7; Q9NPD4
Background:
The 7SK snRNA methylphosphate capping enzyme, also known as Bicoid-interacting protein 3 homolog, plays a pivotal role in RNA metabolism. It functions as an S-adenosyl-L-methionine-dependent methyltransferase, adding a methylphosphate cap to the 5'-end of 7SK snRNA, which stabilizes the RNA molecule. Beyond its enzymatic role, it is integral to the 7SK RNP complex, regulating transcription elongation by sequestering the positive transcription elongation factor b (P-TEFb) and promoting snRNA gene transcription via interaction with the little elongation complex (LEC).
Therapeutic significance:
Understanding the role of 7SK snRNA methylphosphate capping enzyme could open doors to potential therapeutic strategies.