Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q7L576
UPID:
CYFP1_HUMAN
Alternative names:
Specifically Rac1-associated protein 1; p140sra-1
Alternative UPACC:
Q7L576; A8K6D9; Q14467; Q5IED0; Q6ZSX1; Q9BSD9; Q9BVC7
Background:
Cytoplasmic FMR1-interacting protein 1, also known as Specifically Rac1-associated protein 1 or p140sra-1, plays a pivotal role in cellular processes. It is a key component of the CYFIP1-EIF4E-FMR1 complex, mediating translational repression and involved in actin filament reorganization. This protein facilitates the translation repression activity of FMR1 in the brain, regulates membrane ruffle and lamellipodia formation, and is crucial for axon outgrowth and epithelial morphogenesis.
Therapeutic significance:
Understanding the role of Cytoplasmic FMR1-interacting protein 1 could open doors to potential therapeutic strategies.