Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q7RTU9
UPID:
STRC_HUMAN
Alternative names:
-
Alternative UPACC:
Q7RTU9
Background:
Stereocilin, encoded by the gene with accession number Q7RTU9, plays a pivotal role in hearing. It is essential for the formation of horizontal top connectors between outer hair cell stereocilia, structures critical for sound perception.
Therapeutic significance:
Stereocilin's involvement in autosomal recessive deafness, 16, and deafness-infertility syndrome highlights its potential as a target for therapeutic intervention. Understanding the role of Stereocilin could open doors to potential therapeutic strategies.