Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q7RTV0
UPID:
PHF5A_HUMAN
Alternative names:
Splicing factor 3B-associated 14 kDa protein
Alternative UPACC:
Q7RTV0; Q9UH06
Background:
PHD finger-like domain-containing protein 5A, also known as Splicing factor 3B-associated 14 kDa protein, plays a pivotal role in transcriptional elongation by RNA polymerase II. It is essential for embryonic stem cell pluripotency, self-renewal, and myogenic differentiation. This protein is involved in pre-mRNA splicing as part of the SF3B complex, crucial for the assembly of 'A' complex in pre-mRNA, and acts as a transcriptional regulator by enhancing GJA1/Cx43 promoter up-regulation.
Therapeutic significance:
Understanding the role of PHD finger-like domain-containing protein 5A could open doors to potential therapeutic strategies.